Fig. 1
From: Impact of charge patches on tumor disposition and biodistribution of therapeutic antibodies
Model of tumor uptake, used antibody variants and study outline. a Processes governing tumor uptake of antibodies and potential impact of surface charge patches. b Sequence alignment of the designed variable regions, with the complementarity-determining regions (CDRs) highlighted in yellow. c Isocontour representation of the three charge-patch variants used in the study. d Design and readout of the in vivo xenograft study