Fig. 4
From: Impact of charge patches on tumor disposition and biodistribution of therapeutic antibodies
Positive charge patches increase liver exposure and reduce muscle uptake, while a balanced surface charge distribution maximizes tumor exposure. Mean AUC0-48 h values following intravenous dosing at 5 mg/kg each in tumor-bearing Balb/c nude mice in organs and tumor were plotted against relative retention on a heparin column (interaction with negative charge). Note that the raw exposures, without correction for residual serum, are plotted here