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Table 1 Biophysical parameters of charge-patch antibody variants

From: Impact of charge patches on tumor disposition and biodistribution of therapeutic antibodies

Molecule

Isoelectric point (pI, calc.)a

Heparin relative retentionb

FcRn relative retentionb

AbNeg

7.66

0.17

-0.38

AbBal

9.00

0.96

0.14

AbPos

9.30

1.64

0.19

  1. aIsoelectric points were calculated using an in-house implementation of European Molecular Biology Open Software Suite (EMBOSS) (Rice et al. 2000)
  2. bResults from heparin and FcRn column chromatography as described by Kraft et al. (Kraft et al. 2019).
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