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Table 5 Validation of spike recovery assay for active ingredients and level 1 impurities using concentrations at 50%, 100%, and 200% of the temporary guidance limits

From: Development and validation of a headspace GC-MS method to evaluate the interconversion of impurities and the product quality of liquid hand sanitizers

	Product A			Product B
	Spike mixture 50%	Spike mixture 100%	Spike mixture 200%	Spike mixture 50%	Spike mixture 100%	Spike mixture 200%
Ethanol	95	90	94	106	100	91
Isopropanol	104	97	101	105	103	99
Benzene	85	86	88	93	97	96
Acetaldehyde	88	94	96	101	94	95
Acetal	84	90	92	105	90	104
Methanol	92	99	97	89	96	94
	Product C			Product D
	Spike mixture 50%	Spike mixture 100%	Spike mixture 200%	Spike mixture 50%	Spike mixture 100%	Spike mixture 200%
Ethanol	102	98	103	103	101	100
Isopropanol	93	86	94	93	92	89
Benzene	107	106	104	100	100	102
Acetaldehyde	94	95	97	94	97	97
Acetal	108	105	108	110	107	109
Methanol	97	100	100	96	98	99

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