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Table 3 Parameter estimates of the MAP Imax model

From: Pharmacokinetic and pharmacodynamic analyses of terlipressin in patients with hepatorenal syndrome

Parametera

Estimate (RSE%)b

95% CIc

B0 (mm Hg)

75.8 (2.2)

72.5–79.3

Imax (mm Hg)

16.2 (32.9)

9.0–37.8

IC50 (ng/mL)

0.260 (85.4)

0.008–1.280

BSV of B0 (CV%)

11.4 (25.6)

8.2–13.9

Additive error of MAP (mm Hg)

6.9 (11.6)

5.4–8.6

  1. BSV, between-subject variability; CI, confidence interval; CV%, coefficient of variation; IC50, concentration of lysine-vasopressin that produces 50% of the maximal response; Imax, maximum change in HR; L-VP, lysine-vasopressin; MAP, mean arterial pressure; RSE, relative standard error
  2. aMAP = B0 + Imax *L-VP/(IC50 + L-VP)
  3. bParameter precision (RSE%) is expressed as CV%
  4. c95% CI estimated by bootstrap method
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