Skip to main content

Table 3 Parameter estimates of the MAP Imax model

From: Pharmacokinetic and pharmacodynamic analyses of terlipressin in patients with hepatorenal syndrome

Parametera Estimate (RSE%)b 95% CIc
B0 (mm Hg) 75.8 (2.2) 72.5–79.3
Imax (mm Hg) 16.2 (32.9) 9.0–37.8
IC50 (ng/mL) 0.260 (85.4) 0.008–1.280
BSV of B0 (CV%) 11.4 (25.6) 8.2–13.9
Additive error of MAP (mm Hg) 6.9 (11.6) 5.4–8.6
  1. BSV, between-subject variability; CI, confidence interval; CV%, coefficient of variation; IC50, concentration of lysine-vasopressin that produces 50% of the maximal response; Imax, maximum change in HR; L-VP, lysine-vasopressin; MAP, mean arterial pressure; RSE, relative standard error
  2. aMAP = B0 + Imax *L-VP/(IC50 + L-VP)
  3. bParameter precision (RSE%) is expressed as CV%
  4. c95% CI estimated by bootstrap method