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Table 4 Parameter estimates of the HR Imax model

From: Pharmacokinetic and pharmacodynamic analyses of terlipressin in patients with hepatorenal syndrome

Parametera Estimate (RSE%)b 95% CI
B0 (bpm) 79 (2.7) 75–84
Imax (bpm) −10.6 (32.9) −24.0 to −5.8
IC50 (ng/mL) 0.251 (65.7) 0.056–1.06
BSV of B0 (CV%) 14.0 (22.5) 10.7–16.9
BSV of Imax (bpm) 4.5 (177.5) 0.03–15.56
Additive error of HR (bpm) 5.2 (12.8) 4.1–6.3
  1. BSV, between-subject variability; CI, confidence interval; CV%, coefficient of variation; HR, heart rate; IC50, concentration of L-VP that produces 50% of the maximal response; Imax, maximum change in HR; L-VP, lysine-vasopressin; RSE, relative standard error
  2. aHR = B0 + Imax * L-VP/(IC50 + L-VP)
  3. bParameter precision (RSE%) is expressed as CV%