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Table 4 Parameter estimates of the HR Imax model

From: Pharmacokinetic and pharmacodynamic analyses of terlipressin in patients with hepatorenal syndrome

Parametera

Estimate (RSE%)b

95% CI

B0 (bpm)

79 (2.7)

75–84

Imax (bpm)

−10.6 (32.9)

−24.0 to −5.8

IC50 (ng/mL)

0.251 (65.7)

0.056–1.06

BSV of B0 (CV%)

14.0 (22.5)

10.7–16.9

BSV of Imax (bpm)

4.5 (177.5)

0.03–15.56

Additive error of HR (bpm)

5.2 (12.8)

4.1–6.3

  1. BSV, between-subject variability; CI, confidence interval; CV%, coefficient of variation; HR, heart rate; IC50, concentration of L-VP that produces 50% of the maximal response; Imax, maximum change in HR; L-VP, lysine-vasopressin; RSE, relative standard error
  2. aHR = B0 + Imax * L-VP/(IC50 + L-VP)
  3. bParameter precision (RSE%) is expressed as CV%
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