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Table 3 Notations of the increase or decrease of the compression work, Kawakita parameters (Pk and a), bulk density and tablet hardness before and after compaction marked by the “+” and the “–” signs. The “++” indicates large increase, “−−” indicates large decrease. “0” indicates no change

From: Understanding the implication of Kawakita model parameters using in-die force-displacement curve analysis for compacted and non-compacted API powders

 

Compression work

Pk

a

Bulk density

Tablet density

Mebeverine

+

+

−−

++

+

Metronidazole

+

+

−

+

0

Norfloxacin

−

−

−

+

−

Metformin

−

−

−

+

−

Ciprofloxacin

−

+

−−

++

++

Secnidazole

+

+

−−

++

−