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Table 3 Notations of the increase or decrease of the compression work, Kawakita parameters (Pk and a), bulk density and tablet hardness before and after compaction marked by the “+” and the “–” signs. The “++” indicates large increase, “−−” indicates large decrease. “0” indicates no change

From: Understanding the implication of Kawakita model parameters using in-die force-displacement curve analysis for compacted and non-compacted API powders

  Compression work Pk a Bulk density Tablet density
Mebeverine + + −− ++ +
Metronidazole + + + 0
Norfloxacin +
Metformin +
Ciprofloxacin + −− ++ ++
Secnidazole + + −− ++