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Table 1 Phase solubilization of RDV in SBE-β-CD in different pH media

From: Molecular docking assisted exploration on solubilization of poorly soluble drug remdesivir in sulfobutyl ether-tycyclodextrin

SBE-β-CD
Conc
(mM)
pH1.5 pH 1.7 pH2.0 pH3.0 pH 3.5 pH 4.0
S S/S0 S S/S0 S S/S0 S S/S0 S S/S0 S S/S0
0.00 1.735 1 1.369 1 25 °C
0.707
1 0.087 1 0.033 1 0.038 1
11.56 8.542 5 7.507 5 5.710 8 0.871 10 0.432 13 0.301 8
23.12 15.926 9 12.614 9 8.406 12 1.253 14 0.602 19 0.458 12
46.24 26.460 15 19.689 14 11.827 17 1.897 22 0.968 30 0.883 23
92.48 39.646 23 24.427 18 14.701 21 3.001 35 1.467 45 1.608 42
184.95 52.206 30 29.939 22 18.887 27 4.667 54 2.465 76 2.836 75
      37 °C        
0.00 2.355 1 1.521 1 0.745 1 0.084 1 0.046 1 0.035 1
11.56 9.250 4 8.573 6 5.869 8 1.130 14 0.505 11 0.369 11
23.12 16.117 7 13.357 9 8.996 12 1.498 18 0.721 16 0.616 18
46.24 26.754 11 23.641 16 11.983 16 2.077 25 1.272 28 1.102 32
92.48 44.248 19 30.012 20 14.280 19 3.071 37 2.330 51 2.130 62
184.95 59.824 25 42.636 28 17.663 24 5.983 72 4.744 104 4.377 127
      45 °C        
0.00 2.352 1 1.594 1 0.927 1 0.109 1 0.060 1 0.047 1
11.56 9.385 4 8.280 5 5.538 6 0.841 8 0.529 9 0.397 9
23.12 15.239 6 14.319 9 8.662 9 1.222 11 0.786 13 0.511 11
46.24 24.685 10 21.357 13 13.484 15 2.104 19 1.700 29 1.502 32
92.48 36.319 15 27.591 17 16.003 17 2.920 27 2.100 35 1.865 40
184.95 42.998 18 30.422 19 26.649 22 3.935 36 3.139 53 4.154 89