Scheme 1From: The degradation of poloxamer 188 in buffered formulation conditionsThe illustration of the chemical reactions that alkylperoxides (ROO•) originating from AAPH react with histidine (A), followed by the addition of second alkylperoxide (ROO•) to reconstitute histidine and tetroxide (B), then the tetroxide decomposes to alkoxyl radicals (RO•) (C)Back to article page