From: The degradation of poloxamer 188 in buffered formulation conditions
Stress type | Compound | Concentration | Buffer system | |
---|---|---|---|---|
Case I | Oxidation | Hydrogen peroxide | 0.1% (w/v) | 10 mM PBS or 10 mM histidine (pH 6.0) |
Case II | Oxidation | FeCl3 | 20 ppm | |
Case III | Oxidation | Fenton | 0.1% (w/v) | |
Case IV | Oxidation | AAPH | 0.1% (w/v) |