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Fig. 3 | AAPS Open

Fig. 3

From: Heat pre-treatment can abolish anti-drug antibody interference in ligand binding pharmacokinetic assays

Fig. 3

Correlation between the difference in measured concentration caused by heat treatment and the ADA titer. ADA titer, defined as the minimal dilution factor where % B/T was below the assay-specific cut point, was determined for each cynomolgus monkey PK study sample and plotted against the difference in measured concentration when analyzed by a traditional ECL assay and an ECL assay with heat pre-treatment (analyte NNC9204-1177). Linear regression was performed, and the regression line is indicated by the solid line

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