Potential Chemical Liability | AHo# | Position | Motif | Domain | % Commercial mAbs (n = 94) |
---|---|---|---|---|---|
Tryptophan Oxidation | 43 | H_FR2 | W | HC | 100 |
Tryptophan Oxidation | 139 | H_FR4 | W | HC | 100 |
Tryptophan Oxidation | 43 | L_FR2 | W | LC | 98.94 |
Tryptophan Oxidation | 54 | H_FR2 | W | HC | 98.94 |
Isomerization | 100 | H_FR3 | DT | HC | 89.36 |
O-Xylosylation | 81 | L_FR3 | GSG | LC | 89.36 |
O-Xylosylation | 83 | L_FR3 | GSG | LC | 85.11 |
Glycation | 47 | L_FR2 | KPG | LC | 80.85 |
Glycation | 148 | L_FR4 | KRT | LC | 79.79 |
Methionine Oxidation | 41 | H_CDR1 | M | HC | 63.83 |
Lysine Hydroxylation | 75 | H_CDR2 | KG | HC | 58.51 |
Methionine Oxidation | 4 | L_FR1 | M | LC | 57.45 |
Lysine Hydroxylation | 50 | H_FR2 | KG | HC | 56.38 |
Glycation | 50 | H_FR2 | KGL | HC | 55.32 |
Glycation | 144 | L_FR4 | KVE | LC | 52.13 |
Methionine Oxidation | 93 | H_FR3 | M | HC | 51.06 |
Glycation | 75 | H_CDR2 | KGR | HC | 48.94 |
Pyroglutamic Acid | 1 | H_FR1 | Q | HC | 48.94 |
Deamidation | 94 | H_FR3 | NS | HC | 47.87 |
Pyroglutamic Acid | 1 | H_FR1 | E | HC | 47.87 |
Glycation | 53 | L_FR2 | KLL | LC | 46.81 |
Isomerization | 17 | L_FR1 | DR | LC | 46.81 |
Glycation | 50 | L_FR2 | KAP | LC | 43.62 |
Isomerization | 137 | H_CDR3 | DY | HC | 42.55 |
O-Sulfation | 138 | H_CDR3 | DY | HC | 42.55 |
Glycation | 14 | H_FR1 | KPG | HC | 39.36 |
Isomerization | 83 | H_FR3 | DN | HC | 38.3 |
Methionine Oxidation | 91 | H_FR3 | M | HC | 37.23 |
Deamidation | 87 | H_FR3 | NT | HC | 36.17 |
Non-Consensus N-linked Glycosylation | 87 | H_FR3 | SKN | HC | 36.17 |
Glycation | 24 | H_FR1 | KAS | HC | 34.04 |
Glycation | 86 | H_FR3 | KNT | HC | 30.85 |
Glycation | 144 | L_FR4 | KLE | LC | 30.85 |
Isomerization | 72 | H_CDR2 | DS | HC | 28.72 |
Glycation | 13 | H_FR1 | KKP | HC | 27.66 |
Isomerization | 76 | L_FR3 | DR | LC | 27.66 |
Isomerization | 83 | H_FR3 | DT | HC | 27.66 |
Glycation | 20 | H_FR1 | KVS | HC | 25.53 |
Deamidation | 42 | L_CDR1 | NW | LC | 24.47 |
Deamidation | 84 | H_FR3 | NS | HC | 24.47 |