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Table 3 Chamber pressure set points and sublimation duration for Kv cycles conducted in each freeze-dryer

From: Technical transfer and commercialisation of lyophilised biopharmaceuticals — application of lyophiliser characterisation and comparability

Set point

Lyophiliser

Pressure, µBar

Sublimation time, h

SP1a

01, 02, Lyostar II

67 (50 mTorr)

4.5

SP2

01, 02, 03, Lyostar II

133 (100 mTorr)

4.0

SP3

01, 02, Lyostar II

200 (150 mTorr)

3.5

  1. aSP1 for Lyo 02 was performed at a pressure of 46 µBar (35 mTorr)