From: PLGA-based nanoparticles for the treatment of cancer: current strategies and perspectives
Method of preparation | Advantages | Disadvantages |
---|---|---|
Emulsion evaporation | Both hydrophobic and hydrophilic drugs can be encapsulated by single and double or multiple emulsion methods respectively. High production rate at a industrial scale. | Difficult to remove residue of stabilizer and solvents. Heating is required for evaporation. W/o/w emulsions are unstable. |
Microfluidics | Fewer amounts of drug and solution were used. Suitable for heat-labile products. The size and shape of the particles are well controlled. Reproducibility. | Microchannels might get clogged. Small production scale. |
Salting out | Suitable for RNA, DNA, proteins, and amino acids. No requirement for heating. | Restricted up-scaling. The purification step is time consuming. Homogenization at a high scale is required. |
Nanoprecipitation | Low energy requirement. Single step process. Reproducibility. | Uneven particle size distribution during mixing. |