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Fig. 4 | AAPS Open

Fig. 4

From: Results from in vitro and in vivo studies evaluating the bioavailability, effects of food, and administration as crushed tablet suspension on vericiguat pharmacokinetics

Fig. 4

Effects of crushing tablets: box plots for A AUC/D (h/L) and B Cmax/D (/L) of vericiguat in plasma following a single oral dose administration of vericiguat 10 mg as intact tablets or as a crushed tablet suspension. Box plots represent the 25th to 75th percentiles; bold horizontal lines represent the median values. n = 29 for each treatment. AUC/D, dose-normalized area under the curve; Cmax/D, dose-normalized maximum plasma concentration

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