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Table 3 Statistical comparison between intact and crushed 10 mg vericiguat tablet (in 900 mL acetate buffer at 37°C at 75 rpm) expressed as F2 value for each pair

From: Results from in vitro and in vivo studies evaluating the bioavailability, effects of food, and administration as crushed tablet suspension on vericiguat pharmacokinetics

pH of dissolution medium

F2 value

Intact tablet vs crushed tablet (immediately after dispersion)

Intact tablet vs crushed tablet

(4 h after dispersion)

4.5

64

64

6.8

64

70

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