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Fig. 10 | AAPS Open

Fig. 10

From: Formulation mitigations for particle formation induced by enzymatic hydrolysis of polysorbate 20 in protein-based drug products: insights from a full-factorial longitudinal study

Fig. 10

Correlations between [LA] and intact [PS20] for mAb X DP stored at 5 °C. The 24 formulations (listed in Table 1) represent unique combinations of [mAb], initial [PS20], and pH. [LA] was quantified by LC–MS; intact [PS20] was quantified by HPLC-ELSD. Correlation coefficient (r) values for formulations with the same initial [PS20] are shown within the plot. Shaded areas represent 95% prediction intervals of the fitted lines

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