Skip to main content
AAPS Open
Fig. 4 | AAPS Open

Fig. 4

From: Formulation mitigations for particle formation induced by enzymatic hydrolysis of polysorbate 20 in protein-based drug products: insights from a full-factorial longitudinal study

Fig. 4

Storage duration with low SVP counts in mAb X DP as a function of [mAb]. The 24 formulations were stored at 5 °C and represent unique combinations of [mAb], initial [PS20], and pH as listed in Table 1. For each formulation, the duration with low cumulative SVPs (< 350 counts for ≥ 2 µm particles/mL) was determined by SVP measurements (using HIAC liquid particle counter) at 12 time points over 24 weeks

Back to article page