Glycopeptide antibiotic drug stability in aqueous solution

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Table 3 Substitution patterns for the homologs of dalbavancin according to the nomenclature of reference [24, 25]

Dalbavancin	R¹	R²	Molecular formula	Molecular weight (Daltons)^a
A0	CH(CH₃)₂	H	C₈₇H₉₈N₁₀O₂₈Cl₂ ·1.6 HCl	1802.7
A1	CH₂CH₂CH₃	H	C₈₇H₉₈N₁₀O₂₈Cl₂ ·1.6 HCl	1802.7
B0	CH₂CH(CH₃)₂	H	C₈₈H₁₀₀N₁₀O₂₈Cl₂ ·1.6 HCl	1816.7
B1	CH₂CH₂CH₂CH₃	H	C₈₈H₁₀₀N₁₀O₂₈Cl₂ ·1.6 HCl	1816.7
B2	CH₂CH(CH₃)₂	CH₃	C₈₉H₁₀₂N₁₀O₂₈Cl₂ ·1.6 HCl	1830.7
Mannosyl aglycone [25]	N/A	H	C₇₀H₆₉N₉O₂₂Cl₂^b	1459.27

^a Specified molecular weight for anhydrous free base
^b Molecular Formula derived from acylglucoronamine-free dalbavancin ([25], Structure II)