Table 2 Mathematical models for comparison of dissolution profiles Amoxicillin-potassium clavulanate 625 mg tablets
Models | Equation |
|---|---|
Zero-order kinetic model | \(\text{Q}\text{t}=\text{Q}0+\text{K}0\text{t}\) |
First-order kinetic model | \(\text{l}\text{o}\text{g}\text{Q}\text{t}=\text{l}\text{o}\text{g}\text{Q}0-\text{k}1\text{t}/2.303\) |
Second-order kinetic model | \(\frac{1}{Q}=k.t+\frac{1}{Qo}\) |
Higuchi kinetic model | \(\text{Q}\text{t}=\text{K}\text{h}\times \text{t}{{}^{1}\!\left/{}_{2}\right.}\) |
Weibull kinetic model | \(log[-ln(1-m\left)\right]=\beta log(t-Ti)-log\alpha\) |
Hixson-Crowell kinetic model | \(\sqrt[ 3]{\text{Q}\text{o}}-\sqrt[3]{\text{Q}\text{t}}=\text{K}\text{h}\text{c}.\text{t}\) |
Korsemeyer-Peppas kinetic model | \(\mathrm{Mt}/\mathrm M\;\propto\;=\;\mathrm{Ktn}\) |