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10 result(s) within Volume 3 of AAPS Open

1. Comparison of rates of nausea side effects for prescription medications from an online patient community versus medication labels: an exploratory analysis

   While medication labels are considered the authoritative resource for medication information, emerging research suggests that patient-generated health data (PGHD) are a valuable tool to understand the ways in ...

   Authors: David A. Blaser, Stephanie Eaneff, James Loudon-Griffiths, Stephanie Roberts, Paulina Phan, Paul Wicks and James Weatherall

   Citation: AAPS Open 2017 3:10

   Content type: Research Published on: 20 November 2017

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2. Plasma modification of microporous polymer membranes for application in biomimetic dissolution studies

   Biorelevant dissolution is an indispensable tool utilized during formulation development and optimization for the prediction of in vivo bioavailability of pharmaceutical agents. Within that framework, membrane...

   Authors: Michael M. Puppolo, Justin R. Hughey, Bruce Weber, Traciann Dillon, David Storey, Elizabeth Cerkez and Susan Jansen-Varnum

   Citation: AAPS Open 2017 3:9

   Content type: Research Published on: 24 October 2017

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3. AAPS Workshop: accelerating pharmaceutical development through predictive stability approaches, April 4–5, 2016

   There has been significant growth in the use of modeling tools to accelerate development and enhance pharmaceutical quality. Among these are empirical and semi-empirical modeling of accelerated stability studi...

   Authors: A. L. Freed, S. T. Colgan, J. D. Kochling and M. S. Alasandro

   Citation: AAPS Open 2017 3:8

   Content type: Meeting report Published on: 6 September 2017

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4. New directions in pharmaceutical amorphous materials and amorphous solid dispersions, a tribute to Professor George Zografi – Proceedings of the June 2016 Land O’Lakes Conference

   The University of Wisconsin-Madison June Land O’Lakes Conference on Research and Development is held every year and is recognized worldwide as a premier teaching conference for pharmaceutical scientists. The c...

   Authors: Ann Newman, Jayne E. Hastedt and Mehran Yazdanian

   Citation: AAPS Open 2017 3:7

   Content type: Meeting report Published on: 11 August 2017

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5. Oral solid self-nanoemulsifying drug delivery systems of candesartan citexetil: formulation, characterization and in vitro drug release studies

   Candesartan cilexetil is an ester prodrug antagonist to angiotensin II receptor type 1 (AT1) used in management of many cardiovascular diseases. The absolute bioavailability of candesartan cilexetil is about (...

   Authors: Halah Hussein Ali and Ahmed Abbas Hussein

   Citation: AAPS Open 2017 3:6

   Content type: Research Published on: 15 June 2017

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6. A review of in vivo and in vitro aspects of alcohol-induced dose dumping

   This review provides a comprehensive list of in vivo and in vitro studies that have investigated alcohol induced dose dumping (AIDD) in modified release dosage forms. Of the numerous classes of drugs commercia...

   Authors: Susan D’Souza, Stephen Mayock and Alger Salt

   Citation: AAPS Open 2017 3:5

   Content type: Review Published on: 7 June 2017

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7. Oral nanoemulsions of candesartan cilexetil: formulation, characterization and in vitro drug release studies

   Nanoemulsion is considered to be a new and exciting field of research that seeks to exploit the attractive properties of components to improve oral delivery of drugs like candesartan cilexetil used in the mana...

   Authors: Halah Hussein Ali and Ahmed Abbas Hussein

   Citation: AAPS Open 2017 3:4

   Content type: Research Published on: 2 June 2017

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8. Relative bioavailability of diazoxide, manufactured at two different international locations, in healthy participants under fasting conditions: an open-label, two-stage, adaptive, sequential two-period crossover study

   Theoretically, calculating the sample size required for achieving the desired power is straightforward with true coefficient of variance (CV) estimates and true test/reference geometric mean ratios (GMRs) of s...

   Authors: Martin Otto Behm, Jialin Xu, Deborah Panebianco and Paul Fackler

   Citation: AAPS Open 2017 3:3

   Content type: Research Published on: 5 May 2017

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9. Non-isothermal stability by linear heating: a fast method for preformulation stability screening of drugs at the discovery and development interface

   The non-isothermal method for prediction of chemical stability of pharmaceuticals has been discussed in the literature for almost half a century but it has not yet been systematically evaluated. The purpose of...

   Authors: Agnes Kairer, Shaoxin Feng, Valentino J. Stella and Thomas K. Karami

   Citation: AAPS Open 2017 3:2

   Content type: Research Published on: 26 April 2017

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10. Analytical approaches to ensure product quality -- AAPS Joint Face-to-Face Meeting of the Stability, the Pharmaceutical Impurities, and the CMC Statistics Focus Groups, April 6^th, 2016 in Gaithersburg, MD

    An AAPS joint face-to-face meeting was held on April 6th, 2016 at MedImmune, Gaithersburg, MD. The meeting was organized by members of the Steering Committees of the Stability Focus Group, the Pharmaceutical I...

    Authors: Kim Huynh-Ba, Greg Larner, Helen Strickland, Dilip Choudhury, Yan Wu, Jeff Hofer, Zhenyu Wang and Timothy Schofield

    Citation: AAPS Open 2017 3:1

    Content type: Meeting report Published on: 14 January 2017

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