Compatibility study of patiromer with juices/liquids and soft foods

AAPS Open

Table 2 Binding of K⁺ from orange juice to patiromer o.s

	Untreated orange juice	Post-incubation of orange juice with patiromer o.s
		Supernatant (unbound K ⁺ )		Residue (patiromer o.s. bound K ⁺ )
		Low ratio	High ratio	Low ratio	High ratio
K ⁺ , mg/L	2040	607	318	–	–
KBC, mmol/g	–	0.2	0.1	1.9	2.0
Relative KBC, %	–	70^a	84^a	10^b	5^b

^aCalculated as a relative percentage from the difference in the K⁺ concentrations of the untreated orange juice and the supernatant
^bCalculated as a relative percentage of the KBC values of the supernatant and the total (the KBC values of the supernatant plus the residue determined in a K-start solution of 200 mM)
The low and high ratios are equivalent to patiromer active moiety doses of 8.4 g and 25.2 g per 80 mL (1/3 cup) of vehicle, respectively
K⁺ Potassium, KBC K⁺-binding capacity, patiromer o.s. Patiromer powder for oral suspension