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Table 7 Summary of t98% values and binning classifications predicted by the three methods described herein

From: Non-isothermal stability by linear heating: a fast method for preformulation stability screening of drugs at the discovery and development interface

Compound # Binning Classification LNISOa t98% (month) CONV.b t98% (month) Abbrev.c t98% (month)
A1 Stable >24 months >24 months >24 months
A2 Stable >24 months >24 months >24 months
A3 Precipitation, Not Processed  --- ---   ---
A4 Unstable 1.0 1.4 1.2
A5 Stable >24 months >24 months >24 months
A6 Stable >24 months >24 months >24 months
A7 Unstable 1.8 2.3 2.5
A8 Stable >24 months (51) >24 months (40) >24 months (31)
A9 Precipitation: Not Processed  --- ---   ---
A10 Stable >24 months >24 months >24 months
A11 Unstable (Non-First Order Kinetics) 1.6 10.0 4.1
A12 Unstable 0.22 0.41 0.33
A13 Unstable 2.4 2.9 2.6
A14 Unstable by LNISO 15.3 >24 months (25.6) >24 months (24.6)
A15 Stable >24 months (37) >24 months (47) >24 months (35)
A16 Unstable (Non-First Order Kinetics) 1.7 7.9 7.8
A17 Stable >24 months (215) >24 months (226) >24 months (365)
A18 Precipitation: Not Processed.  ---  --- ---
  1. a LNISO Non-isothermal by Linear Heating
  2. b CONV. Conventional Isothermal
  3. c Abbrev. Abbreviated Isothermal